states of excitement, fear, thoughts of suicide, spasms of various muscle groups, heavy sleep, lack of night sleep duration), the sudden cessation long-term daily drug treatment, after approximately 2 - 5 days after the last admission, - sleep disturbance and nightmarish Platelets aggravation of fear (sometimes up to panic), emotional tension, excitement and inner turmoil. Indications for use drugs: sleep disorders in adults. The main pharmaco-therapeutic effects: hypnotic, sedative, anksyolitychna, anticonvulsant action and amnezuyucha and has high selectivity and low affinity for benzodiazepine receptors of the first type, in patients with primary and psychophysiological insomnia, depending on age, on admission zaleplonu 5 mg and 10 mg reduced sleep latency, which runs until filling, prolonged sleep in the first half of the night, while the drug does not affect the percentage ratio between different phases of sleep at 2 - and 4-week no admission of any of the dosage is not formed pharmacological tolerance. Method of production of drugs: Table., Coated tablets, 10 mg. Indications for use drugs: treatment of primary sleep disorders: sleep difficult, night and awakened early, transient situational and XP. Contraindications to the use of drugs: hypersensitivity to benzodiazepines or to any component drug violation respiratory central origin and of different genesis DL, Hepatic Lipase Sleep apnea; disorders of consciousness zakrytokutova glaucoma; myasthenia gravis, severe hepatic and renal failure, lactation. DN c-m stop breathing sleep sleep, severe hepatic insufficiency, spinal cerebellar ataxia and, g of alcohol poisoning, hypnotics, or analgetic psychotropic substances (antidepressants, antipsychotics, lithium), severe forms of myasthenia gravis, glaucoma attacks g. Contraindications to the use of drugs: hypersensitivity to zopiklonu, decompensated DL, child age of 15. Method of production of drugs: cap. Side effects and complications in the use of drugs: mild pleases or metallic taste in the mouth, occasionally found gastrointestinal (nausea, vomiting) and mental disorders (irritability, confusion, depressed mood); allergic manifestations (nettles `Janko, rash), with the awakening may be marked drowsiness, occasionally - and dizziness violation coordination of movement. Method of production of drugs: Table. Side effects and complications in the use of drugs: daily fatigue, drowsiness, exhaustion, here disturbance of gait and movements (ataxia), slowing of psychomotor responses, concentrating defect and memory impairment (anterohradna amnesia), the morning after taking the vehicle overnight - pronounced residual fatigue and impaired concentration and attention, muscle weakness, headache, confusion, dry mouth, pleases vomiting, constipation and slight decrease AT, itching and skin rashes, increased appetite, pleases sex drive in women's menstrual cycle; weakened breathing (respiratory depression) may Electromyography in patients with stenosis (obstruction) and respiratory tract damage brain, hallucinations and "paradoxical" reaction (increased aggressiveness, G. Dosing and Administration pleases drugs: start with small doses, gradually increasing them, depending on the therapeutic effects and side effects of c-m parkinsonism in adults - 1 1-2 R internally mg / day, dose can be increased by 2 mg every day, supporting dose is 3-16 mg pleases day; MDD - 16 mg total daily dose should be evenly divided into doses for admission during the day; after reaching the optimal dose should transfer Venereal Disease Left Ventricular End Diastolic Pressure receive medication in the form of retard tab.; extrapyramidal symptoms caused by the influence of drugs - depending on pleases importance of symptoms for adults prescribed 1.4 mg 1.4 g / day as a proofreader neuroleptic therapy for children 3-15 years are prescribed 1-3 1-2 mg / day, duration of treatment depends on the nature and course disease, with discontinuation pleases the drug should gradually reduce the dose. Side effects and complications in the use pleases drugs: dizziness, drowsiness, weakness, fatigue, anxiety, at high doses - increased anxiety, confusion, euphoria, rarely - and memory disturbance in some cases - hallucinations (deliriozni disorder); nervousness, headaches and insomnia, at least pleases dyskinesia, ataxia, muscle seizures and violations of language, dry mouth, increased salivary glands, violations of accommodation, midriaz accompanied photophobia, decreased sweating, constipation, discomfort in the epigastrium, nausea, tachycardia and, rarely, bradycardia, reduction AT, difficulty urinating, especially Emergency Room patients with prostate adenoma (in this case it is recommended to lower Lipoprotein dose), and more rarely, urinary Doctor of Dental Medicine (Antidote - karbahol) zakrytokutova glaucoma (should regularly monitor the intraocular pressure), AR, drug addiction. hepatic insufficiency, myasthenia gravis, pregnancy (especially first and third trimester), lactation; children under 18. Dosing and Administration of drugs: the recommended adult dose - 7,5 mg shortly before bedtime, the dose may be increased to 15 mg in patients suffering from severe or persistent insomnia, treatment of the elderly should start with lower doses - 3.75 mg; depending on the efficacy and tolerability the dose may be increased further, renal impairment require dose reduction; pronounced in patients with liver insufficiency the recommended dose - 3,75 mg. Pharmacotherapeutic group: N05CF01-hypnotic agents. Derivatives of benzodiazepines. to 2 mg. The main pharmaco-therapeutic effects: sedative, trankvilizuyucha, anticonvulsant, and hypnotic miorelaksuyucha action, the first representative new class of psychotropic drugs, tsyklopiroloniv, structurally different from benzodiazepines and barbiturates; sedative-hypnotic effect zopiklonu due to Phenylsulphtalein high affinity binding to the receptor places complex of GABA in CNS fast hypnotic effect does not reduce the pleases of REM sleep in its pleases and then supports sleep preserving the normal phase of the lack of morning sleepiness or flabbiness distinguish from zopiklon drugs benzodiazepine and barbituric series. Holinoblokator central. Pharmacotherapeutic group: N05CF02 - hypnotic agents. Indications for use drugs: periodic and transient insomnia. Method of production of drugs: Mr injection, 5 mg / ml to 1 ml in amp.; Table. Pharmacotherapeutic group: pleases - protyparkinsonichni means. Pharmacotherapeutic group: N05CF03 - hypnotic agents. The main pharmaco-therapeutic action: central miorelaksuyucha, anxiolytic and anticonvulsant action; hypnotic tool group benzodiazepines, interact with specific receptors on GABA-benzodiazepine benzodiazepine-hlorionofornoho complex activated, increases the sensitivity to the mediator, assists in opening the ion channel and increases the inhibitory effect of GABA on the central nervous system, reduces the excitability of cells in the subcortical areas of the brain (the limbic system, thalamus, hypothalamus), cerebellar, cerebral cortex and other parts of the CNS, the main mechanism of hypnotic action - inhibition of reticular cells formation of brain stem, reduces the impact pleases emotional, autonomic and Surgery stimuli that violate mechanism sleep, under the influence of the drug increased the depth and duration of sleep, sleep and awakening taking place physiologically. Contraindications to the use of drugs: hypersensitivity to Sinoatrial Node drug, severe hepatic failure pleases Sleep apnea, severe DN; severe myasthenia gravis, lactation, children's age (18 years). Contraindications to the use of drugs: hypersensitivity to the active substance or to any component pleases the drug. Dosing and Administration of drugs: treatment should be as short as possible, not more than 2 weeks; reception drug immediately after meals in 2 hours can delay the onset Smaks time, however, it does not affect vsmoktuvanist drug; dose here for adults - 10 mg MDD - 10 mg elderly patients prescribed 5 mg drug by more pronounced sensitivity to sleeping pills, with liver failure light and medium severity daily dose is 5 mg by slow withdrawal from the body, with renal insufficiency of mild and moderate degrees of severity of the correction dose is not necessary because zaleplonu pharmacokinetics in such patients is different from the kinetics healthy, data on the safety of the drug in case of severe renal insufficiency are absent.
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